Cerebral concussion in rats rapidly induces hypothalamic-specific effects on opiate and cholinergic receptors
Identifieur interne : 005197 ( Main/Exploration ); précédent : 005196; suivant : 005198Cerebral concussion in rats rapidly induces hypothalamic-specific effects on opiate and cholinergic receptors
Auteurs : Michael West [Canada] ; Frank S. Labella [Canada] ; Viktor Havlicek [Canada] ; Dwight Parkinson [Canada]Source :
- Brain Research [ 0006-8993 ] ; 1981.
English descriptors
- KwdEn :
Abstract
Summary: Conscious male adult rats were concussed by a blow to the occiput with a blunt dart, shot from a spring-loaded pistol. Animals were decapitated within 2 sec, brains quickly removed, several brain regions homogenized in cold buffer and radioreceptor assays carried out. There was a 20% increase in binding of [3H]naloxone and [3H]QNB in the hypothalamus but not in the amygdala, striatum, hippocampus, cortex, midbrain and hindbrain. For animals killed 5–10 sec after concussion, when normal conscious behavior had returned, there were no changes in binding between control and concussed rats. Binding of [3H]spiroperidol and [3H]ouabain was unaffected by concussion. To rule out changes due to non-specific stress, one series of rats received a blow to the lower body. There was no change from control in [3H]QNB binding to hypothalamic tissues by a body blow as compared with the blow to the head. The findings suggests decreased binding of endogenous endorphins and acetylcholine to their respective receptors as a result of concussion. The transient deficit in endogenous transmitter binding may temporarily interrupt hypothalamic circuits concerned with the state of consciousness.
Url:
DOI: 10.1016/0006-8993(81)90835-0
Affiliations:
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Labella</name></author><author><name sortKey="Havlicek, Viktor" sort="Havlicek, Viktor" uniqKey="Havlicek V" first="Viktor" last="Havlicek">Viktor Havlicek</name></author><author><name sortKey="Parkinson, Dwight" sort="Parkinson, Dwight" uniqKey="Parkinson D" first="Dwight" last="Parkinson">Dwight Parkinson</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9A0F293CE87B9E47C6F7CABF5019BB1960DBE3A2</idno><date when="1981" year="1981">1981</date><idno type="doi">10.1016/0006-8993(81)90835-0</idno><idno type="url">https://api-v5.istex.fr/document/9A0F293CE87B9E47C6F7CABF5019BB1960DBE3A2/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000679</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000679</idno><idno type="wicri:Area/Istex/Curation">000679</idno><idno type="wicri:Area/Istex/Checkpoint">002759</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002759</idno><idno type="wicri:doubleKey">0006-8993:1981:West M:cerebral:concussion:in</idno><idno type="wicri:Area/Main/Merge">005C11</idno><idno type="wicri:Area/Main/Curation">005197</idno><idno type="wicri:Area/Main/Exploration">005197</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cerebral concussion in rats rapidly induces hypothalamic-specific effects on opiate and cholinergic receptors</title><author><name sortKey="West, Michael" sort="West, Michael" uniqKey="West M" first="Michael" last="West">Michael West</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Physiology, Pharmacology and Therapeutics, and of Neurological Surgery, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Labella, Frank S" sort="Labella, Frank S" uniqKey="Labella F" first="Frank S." last="Labella">Frank S. Labella</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Physiology, Pharmacology and Therapeutics, and of Neurological Surgery, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Havlicek, Viktor" sort="Havlicek, Viktor" uniqKey="Havlicek V" first="Viktor" last="Havlicek">Viktor Havlicek</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Physiology, Pharmacology and Therapeutics, and of Neurological Surgery, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Parkinson, Dwight" sort="Parkinson, Dwight" uniqKey="Parkinson D" first="Dwight" last="Parkinson">Dwight Parkinson</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Physiology, Pharmacology and Therapeutics, and of Neurological Surgery, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="ISSN">0006-8993</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1981">1981</date><biblScope unit="volume">225</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="271">271</biblScope><biblScope unit="page" to="277">277</biblScope></imprint><idno type="ISSN">0006-8993</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>acetylcholine receptor</term><term>concussion</term><term>hypothalamus</term><term>neurotransmitter receptor</term><term>opiate receptor</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Conscious male adult rats were concussed by a blow to the occiput with a blunt dart, shot from a spring-loaded pistol. Animals were decapitated within 2 sec, brains quickly removed, several brain regions homogenized in cold buffer and radioreceptor assays carried out. There was a 20% increase in binding of [3H]naloxone and [3H]QNB in the hypothalamus but not in the amygdala, striatum, hippocampus, cortex, midbrain and hindbrain. For animals killed 5–10 sec after concussion, when normal conscious behavior had returned, there were no changes in binding between control and concussed rats. Binding of [3H]spiroperidol and [3H]ouabain was unaffected by concussion. To rule out changes due to non-specific stress, one series of rats received a blow to the lower body. There was no change from control in [3H]QNB binding to hypothalamic tissues by a body blow as compared with the blow to the head. The findings suggests decreased binding of endogenous endorphins and acetylcholine to their respective receptors as a result of concussion. The transient deficit in endogenous transmitter binding may temporarily interrupt hypothalamic circuits concerned with the state of consciousness.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Manitoba</li></region><settlement><li>Winnipeg</li></settlement><orgName><li>Université du Manitoba</li></orgName></list><tree><country name="Canada"><region name="Manitoba"><name sortKey="West, Michael" sort="West, Michael" uniqKey="West M" first="Michael" last="West">Michael West</name></region><name sortKey="Havlicek, Viktor" sort="Havlicek, Viktor" uniqKey="Havlicek V" first="Viktor" last="Havlicek">Viktor Havlicek</name><name sortKey="Labella, Frank S" sort="Labella, Frank S" uniqKey="Labella F" first="Frank S." last="Labella">Frank S. 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